Association of foxo3 blood dna methylation with cancer risk, cancer survival, and mortality

C Yu; AM Hodge; EM Wong; JE Joo; E Makalic; D Schmidt; DD Buchanan; JL Hopper; GG Giles; MC Southey; PA Dugué

Journal article

Association of foxo3 blood dna methylation with cancer risk, cancer survival, and mortality

C Yu, AM Hodge, EM Wong, JE Joo, E Makalic, D Schmidt, DD Buchanan, JL Hopper, GG Giles, MC Southey, PA Dugué

Cells | Published : 2021

DOI: 10.3390/cells10123384

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Abstract

Genetic variants in FOXO3 are associated with longevity. Here, we assessed whether blood DNA methylation at FOXO3 was associated with cancer risk, survival, and mortality. We used data from eight prospective case–control studies of breast (n = 409 cases), colorectal (n = 835), gastric (n = 170), kidney (n = 143), lung (n = 332), prostate (n = 869), and urothelial (n = 428) cancer and B-cell lymphoma (n = 438). Case–control pairs were matched on age, sex, country of birth, and smoking (lung cancer study). Conditional logistic regression was used to assess associations between cancer risk and methylation at 45 CpGs of FOXO3 included on the HumanMethylation450 assay. Mixed-effects Cox models we..

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University of Melbourne Researchers

Allison Hodge Author

Eric Joo Author

Enes Makalic Author

Daniel Schmidt Author Melbourne School of Population and Global Health

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Grants

Awarded by VicHealth

Funding Acknowledgements

MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria, Australia. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC grants 1011618, 1026892, 1027505, 1050198, 1043616 and 1074383. This work was further supported by NHMRC grants 1088405 and 1164455. M.C.S. is a recipient of a Senior Research Fellowship from the NHMRC (GTN1155163).